While there are very few and generally very rare contraindications to usage of i.v. vitamin C, here some of them.
1. Counter indications to this approach are few. However they include anyone with kidney failure, or on dialysis, or with uncommon forms of iron overload. Responsible physicians should also screen for red blood cell glucose-6 phosphate dehydrogenase deficiency, a rare condition whose presence can lead to haemolytic crisis involving red blood cell breakdown. The very large doses should also be built up to gradually over some days to establish good tolerance, starting at 15 grams for 1 or 2 sessions, then to 50 grams and, if necessary, to 100 grams. The exact dose is determined by the individuals plasma saturation by Vitamin C immediately after an infusion. WARNING: To avoid the well-documented Rebound Effect, which can lead to scurvy, this treatment should not be stopped abruptly. Patients should be gradually weaned off it over a period of weeks, or even months, and oral vitamin C therapy should continue indefinitely and on the days in between the intravenous vitamin C infusions.
2. Diabetes - false positive alarm (???)

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Intravenous vitamin C for Cancer